Erythrocyte homeostasis

Across TCGA cell cohorts, RNA activity of the Erythrocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAOK3, TMEM86B, and KLHL35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAOK3 grouped by Erythrocyte homeostasis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TAOK3 →	+1.092	+0.229	.002	.008	3	5
BREAST	TMEM86B →	+0.767	+0.169	.003	.001	3	5
BLOOD_Leukemia	KLHL35 →	+1.174	+0.203	.005	.001	3	4
LUNG_SCLC	RHOC →	-1.921	-0.334	.009	.004	3	4
LUNG_SCLC	TIGD4 →	+0.643	+0.231	.001	.006	3	4
KIDNEY	HELB →	+0.424	+0.299	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAOK3 by Erythrocyte homeostasis activity — OVARY

Explore this box plot interactively →