Erythrocyte homeostasis

Across TCGA cell cohorts, RNA activity of the Erythrocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM7A, CEBPG, and SLX1A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte homeostasis activity versus KDM7A in STOMACH (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KDM7A →	+1.417	+0.049	.003	.007	3	10
LARGE_INTESTINE	CEBPG →	+0.815	+0.074	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	SLX1A →	-1.096	-0.051	<.001	<.001	3	7
SKIN	MPG →	-0.788	-0.041	.003	.003	3	7
LUNG_NSCLC_LUSC	SLC39A13 →	-1.647	-0.070	.002	.002	3	6
LARGE_INTESTINE	OGFR →	-0.937	-0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034101 vs KDM7A — STOMACH

Explore this scatter interactively →