Positive regulation of maintenance of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of maintenance of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACER2, SOX12, and AZI2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACER2 grouped by Positive regulation of maintenance of sister chromatid cohesion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACER2 →	+1.683	+1.162	<.001	.004	3	4
LIVER	SOX12 →	-0.715	-1.227	.008	<.001	3	4
BONE	AZI2 →	-0.696	-1.496	.001	.002	3	4
BREAST	TM9SF1 →	+0.690	+0.307	<.001	.001	3	4
BREAST	PRSS22 →	+1.540	+0.263	.006	.008	3	4
LUNG_NSCLC_LUAD	MATN2 →	-1.612	-0.426	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACER2 by Positive regulation of maintenance of sister chromatid cohesion activity — STOMACH

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