Regulation of maintenance of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Regulation of maintenance of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYVE1, PTGER2, and S1PR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of maintenance of sister chromatid cohesion activity versus LYVE1 in BRCA (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LYVE1 →	-1.366	-0.644	<.001	.002	3	6
BRCA	PTGER2 →	-0.931	-0.684	<.001	<.001	3	5
BRCA	S1PR1 →	-1.005	-0.774	<.001	<.001	3	5
LSCC	CXCR2 →	-1.083	-1.415	<.001	<.001	3	5
LSCC	FANCA →	+0.398	+0.821	.004	.005	3	5
BRCA	GABARAPL1 →	-0.669	-0.597	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034091 vs LYVE1 — BRCA

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