Regulation of maintenance of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Regulation of maintenance of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPUSD2, NAA10, and SLC6A14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPUSD2 grouped by Regulation of maintenance of sister chromatid cohesion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPUSD2 →	+0.498	+0.171	<.001	.001	3	5
SKIN	NAA10 →	-0.607	-0.186	.001	.007	3	5
STOMACH	SLC6A14 →	+1.998	+0.322	.002	.003	3	4
LUNG_SCLC	RALGPS2 →	+2.061	+0.295	.003	.008	3	4
UPPER_AERODIGESTIVE_TRACT	RHOV →	+2.533	+0.262	.004	.001	3	4
STOMACH	FXYD3 →	+5.173	+0.471	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPUSD2 by Regulation of maintenance of sister chromatid cohesion activity — OVARY

Explore this box plot interactively →