Establishment of mitotic sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Establishment of mitotic sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POGZ, SMC1A, and PSIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of mitotic sister chromatid cohesion activity versus POGZ in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POGZ →	+0.440	+0.139	<.001	<.001	3	6
LSCC	SMC1A →	+0.279	+0.049	.004	.002	3	6
GBM	PSIP1 →	+0.557	+0.042	<.001	<.001	3	6
BRCA	TBRG4 →	-0.293	-0.036	<.001	.005	3	5
OV	RPL5 →	-0.194	-0.077	.002	.002	3	5
HNSC	RIN1_S337 →	-0.635	-0.157	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034087 vs POGZ — HNSC

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