Establishment of mitotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Establishment of mitotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF9, ANXA6, and DENND2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF9 grouped by Establishment of mitotic sister chromatid cohesion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLF9 →	-1.540	-0.245	.002	.002	3	4
LIVER	ANXA6 →	-3.060	-0.338	.002	.003	3	3
SOFT_TISSUE	DENND2A →	+2.775	+0.272	.001	.007	3	3
SOFT_TISSUE	SMPDL3A →	+2.578	+0.379	.001	.007	3	3
OESOPHAGUS	CCDC69 →	+1.188	+0.176	.004	.002	3	3
LUNG_SCLC	SCD5 →	+1.928	+0.390	.005	.009	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF9 by Establishment of mitotic sister chromatid cohesion activity — SOFT_TISSUE

Explore this box plot interactively →