Establishment of mitotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Establishment of mitotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VGLL4, ACTR3B, and CALHM6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of mitotic sister chromatid cohesion activity versus VGLL4 in BREAST (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VGLL4 →	+1.283	+0.231	<.001	<.001	3	5
BLOOD_Myeloma	ACTR3B →	+1.242	+0.304	<.001	.005	3	5
OVARY	CALHM6 →	-1.460	-0.209	.005	<.001	3	5
CNS	ING5 →	+0.676	+0.178	<.001	<.001	2	5
LUNG_NSCLC_LUAD	EZH2 →	+0.534	+0.121	<.001	.001	3	4
LUNG_NSCLC_LUAD	DSCC1 →	+0.753	+0.100	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034087 vs VGLL4 — BREAST

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