Maintenance of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Maintenance of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, LYVE1, and IL1RL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of sister chromatid cohesion activity versus AOC3 in LSCC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AOC3 →	-0.902	-1.183	<.001	<.001	3	6
GBM	LYVE1 →	-1.354	-1.078	<.001	<.001	3	6
BRCA	IL1RL1 →	-0.613	-0.624	<.001	.002	3	6
BRCA	PBK →	+1.268	+1.165	<.001	<.001	3	5
GBM	CXCR2 →	-0.663	-0.901	<.001	<.001	3	5
BRCA	MYLK →	-0.742	-1.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034086 vs AOC3 — LSCC

Explore this scatter interactively →