Maintenance of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Maintenance of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE2, TMEM131L, and SIN3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPNE2 grouped by Maintenance of sister chromatid cohesion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CPNE2 →	-1.257	-0.664	<.001	.003	2	5
STOMACH	TMEM131L →	-0.994	-0.258	.008	.002	3	3
STOMACH	SIN3B →	-1.001	-0.336	.001	.002	3	3
OVARY	USF1 →	-0.640	-1.006	.005	.005	3	3
STOMACH	RFLNB →	-3.412	-0.360	.001	.003	3	3
STOMACH	PHLDB1 →	-2.008	-0.239	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPNE2 by Maintenance of sister chromatid cohesion activity — CNS

Explore this box plot interactively →