Maintenance of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Maintenance of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFYVE27, CEP57L1, and PDIA6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of sister chromatid cohesion activity versus ZFYVE27 in BLOOD_Lymphoma (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZFYVE27 →	+0.661	+0.387	.002	.003	3	3
BLOOD_Lymphoma	CEP57L1 →	-0.941	-0.366	.007	.007	3	3
PANCREAS	PDIA6 →	-0.759	-0.236	.001	.005	3	3
BLOOD_Lymphoma	NDUFAF5 →	-0.815	-0.340	.004	.009	2	3
BLOOD_Lymphoma	CASP2 →	+0.724	+0.276	.009	.008	3	2
BLOOD_Lymphoma	ATP6V1A →	-1.210	-0.409	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034086 vs ZFYVE27 — BLOOD_Lymphoma

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