Establishment of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Establishment of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP300, CEP128, and SMCHD1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of sister chromatid cohesion activity versus EP300 in DLBC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	EP300 →	+2.225	+0.080	<.001	<.001	3	34
THYM	CEP128 →	+1.574	+0.067	<.001	<.001	3	34
DLBC	SMCHD1 →	+1.415	+0.067	<.001	<.001	3	34
DLBC	USP42 →	+1.008	+0.063	<.001	<.001	3	34
DLBC	ASH1L →	+1.529	+0.072	<.001	<.001	3	34
DLBC	STAG1 →	+1.864	+0.080	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034085 vs EP300 — DLBC

Explore this scatter interactively →