Establishment of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Establishment of sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCES, DAXX, and GABPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of sister chromatid cohesion activity versus HMCES in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMCES →	+0.294	+0.040	<.001	<.001	3	6
UCEC	DAXX →	+0.251	+0.065	<.001	<.001	3	6
LSCC	GABPA →	+0.201	+0.062	.001	.003	3	5
COAD	MEN1 →	+0.328	+0.043	.003	.001	3	5
HNSC	BRD4 →	+0.176	+0.066	.002	.001	3	5
HNSC	RFC3 →	+0.330	+0.104	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034085 vs HMCES — BRCA

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