Establishment of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Establishment of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAG1, DIPK2B, and MTND6P3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of sister chromatid cohesion activity versus IRAG1 in GBM (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IRAG1 →	-0.986	-0.357	<.001	<.001	3	4
OV	DIPK2B →	-0.542	-0.304	.001	.001	3	3
LSCC	MTND6P3 →	-0.150	-0.205	.006	.008	3	3
GBM	TTC31 →	+0.308	+0.406	.003	.003	3	3
GBM	MDC1 →	+0.497	+0.423	<.001	.001	3	3
GBM	MIR556 →	+0.896	+0.266	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034085 vs IRAG1 — GBM

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