Establishment of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Establishment of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, KLF9, and PMP22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPARC grouped by Establishment of sister chromatid cohesion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SPARC →	-6.203	-0.324	<.001	.002	3	4
SOFT_TISSUE	KLF9 →	-1.728	-0.271	.002	.008	3	4
LIVER	PMP22 →	-2.495	-0.309	.001	.004	2	4
LIVER	ANXA6 →	-3.226	-0.306	.002	.002	3	3
LIVER	SMIM3 →	-2.051	-0.338	.002	.005	3	3
OVARY	SPG11 →	-0.661	-0.902	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPARC by Establishment of sister chromatid cohesion activity — LIVER

Explore this box plot interactively →