CENP-A containing chromatin assembly

Across TCGA cell cohorts, RNA activity of the CENP-A containing chromatin assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K6, SOX12, and NATD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K6 grouped by CENP-A containing chromatin assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP3K6 →	-1.241	-0.314	<.001	<.001	3	4
SKIN	SOX12 →	-0.748	-0.929	.001	.008	2	5
BLOOD_Leukemia	NATD1 →	-0.701	-0.637	.008	.009	3	3
URINARY_TRACT	FA2H →	+1.825	+1.723	.007	.005	2	4
URINARY_TRACT	EIF5A →	-0.934	-1.722	.003	.006	3	3
URINARY_TRACT	FUBP1 →	-0.563	-1.384	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K6 by CENP-A containing chromatin assembly activity — BREAST

Explore this box plot interactively →