CENP-A containing chromatin assembly

Across TCGA cell cohorts, RNA activity of the CENP-A containing chromatin assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPI, BUB1, and BIRC5, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CENP-A containing chromatin assembly activity versus CENPI in LUNG_NSCLC_LUSC (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CENPI →	+1.224	+0.137	<.001	<.001	3	20
KIDNEY	BUB1 →	+1.465	+0.179	<.001	<.001	3	20
URINARY_TRACT	BIRC5 →	+1.464	+0.178	<.001	<.001	3	19
PANCREAS	CLSPN →	+1.794	+0.154	<.001	<.001	3	19
BONE	MCM10 →	+1.626	+0.234	.003	.001	3	19
BLOOD_Myeloma	RAD54L →	+1.697	+0.201	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034080 vs CENPI — LUNG_NSCLC_LUSC

Explore this scatter interactively →