Protein localization to Golgi apparatus

Across TCGA patient cohorts, RNA activity of the Protein localization to Golgi apparatus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL6, CSNK1A1, and C1S, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to Golgi apparatus activity versus RPL6 in BRCA (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL6 →	-0.393	-0.039	.001	.008	3	6
LSCC	CSNK1A1 →	-0.435	-0.045	<.001	<.001	3	5
OV	C1S →	+0.554	+0.069	<.001	<.001	3	5
LSCC	COPZ2 →	+0.490	+0.037	.001	.006	3	5
CCRCC	HAPLN3 →	+0.640	+0.050	.001	.003	3	5
OV	MTPAP →	-0.354	-0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034067 vs RPL6 — BRCA

Explore this scatter interactively →