Protein localization to Golgi apparatus

Across TCGA patient cohorts, RNA activity of the Protein localization to Golgi apparatus pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMCO1-AS1, FDPSP4, and SDC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to Golgi apparatus activity versus TMCO1-AS1 in LSCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMCO1-AS1 →	-0.340	-0.140	.009	.001	3	4
CCRCC	FDPSP4 →	-0.210	-0.155	.007	.002	3	4
CCRCC	SDC4 →	+0.621	+0.160	<.001	<.001	3	4
CCRCC	IER3-AS1 →	-0.563	-0.170	.003	<.001	3	4
LUAD	TUBB1 →	-0.290	-0.154	<.001	.002	3	4
CCRCC	RASL12 →	-0.640	-0.139	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034067 vs TMCO1-AS1 — LSCC

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