Protein localization to Golgi apparatus

Across TCGA cell cohorts, RNA activity of the Protein localization to Golgi apparatus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJB2, C6orf132, and KRTAP5-9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GJB2 grouped by Protein localization to Golgi apparatus-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GJB2 →	+1.990	+0.402	.001	.001	3	5
LUNG_NSCLC_LUAD	C6orf132 →	+1.093	+0.374	.008	.003	3	4
URINARY_TRACT	KRTAP5-9 →	-0.065	-0.561	<.001	<.001	3	3
OESOPHAGUS	RSBN1 →	-1.103	-0.541	.003	.001	3	3
LARGE_INTESTINE	CYB5B →	-0.795	-0.516	.003	.005	3	3
LUNG_NSCLC_LUAD	PTOV1 →	+0.531	+0.248	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GJB2 by Protein localization to Golgi apparatus activity — OESOPHAGUS

Explore this box plot interactively →