Protein localization to Golgi apparatus

Across TCGA cell cohorts, RNA activity of the Protein localization to Golgi apparatus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED10, CPNE7, and MYG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to Golgi apparatus activity versus TMED10 in BLOOD_Myeloma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TMED10 →	+0.903	+0.987	.008	.007	2	8
LUNG_NSCLC_LUAD	CPNE7 →	-1.692	-0.871	<.001	.001	3	7
OVARY	MYG1 →	-0.744	-1.067	<.001	<.001	3	6
PANCREAS	MARVELD3 →	+2.644	+1.381	.002	<.001	2	7
URINARY_TRACT	C1orf210 →	+2.992	+1.432	.001	<.001	3	6
PANCREAS	TMEM125 →	+3.588	+1.576	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034067 vs TMED10 — BLOOD_Myeloma

Explore this scatter interactively →