Stress granule assembly

Across TCGA patient cohorts, RNA activity of the Stress granule assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACIN1_S243, RPL26, and RALY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress granule assembly activity versus ACIN1_S243 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACIN1_S243 →	+0.352	+0.034	<.001	<.001	3	5
LUAD	RPL26 →	-0.508	-0.043	.003	.006	3	5
HNSC	RALY →	+0.244	+0.103	<.001	<.001	3	5
GBM	RPL28 →	-0.366	-0.046	<.001	<.001	3	5
HNSC	PDLIM1 →	-0.233	-0.069	.004	.006	3	5
LUAD	CRYBG3 →	-0.315	-0.047	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034063 vs ACIN1_S243 — BRCA

Explore this scatter interactively →