Stress granule assembly

Across TCGA patient cohorts, RNA activity of the Stress granule assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPOR2, COX7A1, and RACGAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress granule assembly activity versus RIPOR2 in CCRCC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RIPOR2 →	-0.688	-0.196	<.001	<.001	3	6
CCRCC	COX7A1 →	-1.154	-0.241	<.001	<.001	3	6
HNSC	RACGAP1 →	+1.007	+0.125	.005	.008	2	6
LSCC	SCYL2 →	+0.418	+0.136	<.001	.003	3	5
PDAC	TMED2 →	+0.207	+0.088	.004	.001	3	5
LSCC	GMFG →	-0.563	-0.145	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034063 vs RIPOR2 — CCRCC

Explore this scatter interactively →