Endosomal vesicle fusion

Across TCGA patient cohorts, RNA activity of the Endosomal vesicle fusion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPEP2, EMP3, and FLI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosomal vesicle fusion activity versus DPEP2 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DPEP2 →	+0.522	+0.152	.003	.001	3	5
BRCA	EMP3 →	+0.468	+0.118	<.001	<.001	3	4
LSCC	FLI1 →	+0.650	+0.118	<.001	.005	3	4
LUAD	SLA →	+0.396	+0.120	.006	<.001	3	4
LSCC	CYRIA →	+0.603	+0.168	<.001	<.001	3	4
BRCA	IFFO1 →	+0.515	+0.113	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034058 vs DPEP2 — BRCA

Explore this scatter interactively →