Endosomal vesicle fusion

Across TCGA cell cohorts, RNA activity of the Endosomal vesicle fusion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS9, CAT, and PHB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INTS9 grouped by Endosomal vesicle fusion-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	INTS9 →	-1.152	-0.303	<.001	.001	3	3
KIDNEY	CAT →	-0.872	-0.280	.002	.003	3	3
KIDNEY	PHB →	-0.534	-0.276	<.001	.004	3	3
CNS	MEST →	+3.305	+0.475	.001	.004	3	3
LUNG_NSCLC_LUSC	TMEM94 →	-0.696	-0.399	.002	<.001	3	3
CNS	PIGB →	-0.436	-0.386	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INTS9 by Endosomal vesicle fusion activity — BONE

Explore this box plot interactively →