P-body assembly

Across TCGA patient cohorts, RNA activity of the P-body assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLK_S518, CAST_S499, and SND1_S645, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, P-body assembly activity versus SLK_S518 in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLK_S518 →	-0.671	-0.050	<.001	<.001	3	5
GBM	CAST_S499 →	-0.721	-0.054	.001	<.001	3	5
HNSC	SND1_S645 →	-0.629	-0.094	<.001	.001	3	5
HNSC	TRIM28 →	+0.281	+0.084	<.001	<.001	3	5
CCRCC	WIPF2 →	-0.143	-0.031	.006	.002	3	5
HNSC	MED13L_S878 →	+0.492	+0.079	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033962 vs SLK_S518 — LSCC

Explore this scatter interactively →