P-body assembly

Across TCGA patient cohorts, RNA activity of the P-body assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR2, CD69, and XPOT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, P-body assembly activity versus C5AR2 in LUAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C5AR2 →	-0.616	-0.206	.001	<.001	3	5
LSCC	CD69 →	-0.508	-0.130	.006	.002	3	5
LSCC	XPOT →	+0.382	+0.165	.007	<.001	3	5
UCEC	JADE3 →	+0.454	+0.187	.001	.007	1	6
CCRCC	GORASP2 →	+0.253	+0.181	.008	.005	2	5
CCRCC	STARD8 →	-0.651	-0.225	.002	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033962 vs C5AR2 — LUAD

Explore this scatter interactively →