Response to glucagon

Across TCGA patient cohorts, RNA activity of the Response to glucagon pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCPS, CLUH, and NUP98_T546, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to glucagon activity versus DCPS in COAD (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DCPS →	-0.243	-0.044	.001	.002	3	5
UCEC	CLUH →	+0.220	+0.074	<.001	<.001	3	5
COAD	NUP98_T546 →	+0.315	+0.046	<.001	.003	3	4
LUAD	TK1 →	+0.441	+0.079	<.001	<.001	3	4
UCEC	AKAP13_S983 →	+0.408	+0.077	.004	.001	3	4
LSCC	KRR1 →	+0.341	+0.064	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033762 vs DCPS — COAD

Explore this scatter interactively →