Response to glucagon

Across TCGA patient cohorts, RNA activity of the Response to glucagon pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFCAB11, IGBP1P1, and GJA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to glucagon activity versus EFCAB11 in OV (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFCAB11 →	+0.397	+0.127	<.001	.002	3	3
OV	IGBP1P1 →	+0.436	+0.138	.001	.002	3	3
PDAC	GJA3 →	+0.167	+0.118	.006	.005	3	3
UCEC	HOXB13 →	+1.149	+0.281	.001	<.001	3	3
LUAD	RNU6ATAC24P →	-0.315	-0.100	<.001	.002	3	3
UCEC	CCDC183 →	+0.362	+0.274	.007	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033762 vs EFCAB11 — OV

Explore this scatter interactively →