Response to glucagon

Across TCGA cell cohorts, RNA activity of the Response to glucagon pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP9, CHST13, and USP6NL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FKBP9 grouped by Response to glucagon-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FKBP9 →	+0.921	+0.272	.001	.001	3	4
LUNG_NSCLC_LUAD	CHST13 →	-0.449	-0.236	.008	.002	3	4
LUNG_SCLC	USP6NL →	+0.855	+0.256	<.001	.001	2	4
LIVER	CDK2 →	+0.971	+0.350	.002	.002	3	3
LIVER	FBXO21 →	+0.661	+0.330	.002	<.001	3	3
LIVER	DBNL →	+1.477	+0.442	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FKBP9 by Response to glucagon activity — PANCREAS

Explore this box plot interactively →