Response to glucagon

Across TCGA cell cohorts, RNA activity of the Response to glucagon pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRRD, DTWD1, and CHMP2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to glucagon activity versus SRRD in PANCREAS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SRRD →	-0.985	-0.286	.002	.002	3	4
BLOOD_Myeloma	DTWD1 →	+1.008	+0.421	.001	.003	3	4
SOFT_TISSUE	CHMP2A →	+1.053	+0.460	.001	.001	3	4
SKIN	EPHA2 →	-2.080	-0.225	<.001	.009	3	4
LARGE_INTESTINE	LACTB →	+0.692	+0.259	.002	.006	2	5
SKIN	ZNF622 →	+0.740	+0.323	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033762 vs SRRD — PANCREAS

Explore this scatter interactively →