Phospholipid efflux

Across TCGA patient cohorts, RNA activity of the Phospholipid efflux pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYVE1, VIM, and SERPINE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid efflux activity versus LYVE1 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LYVE1 →	+1.015	+0.086	.002	.002	3	6
PDAC	VIM →	+0.412	+0.091	<.001	<.001	3	6
GBM	SERPINE1 →	+1.508	+0.099	<.001	.001	3	5
GBM	CD93 →	+0.814	+0.095	<.001	.003	3	5
LUAD	HAS1 →	+0.688	+0.067	<.001	<.001	3	5
LUAD	MMRN1 →	+0.695	+0.064	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033700 vs LYVE1 — GBM

Explore this scatter interactively →