Phospholipid efflux

Across TCGA cell cohorts, RNA activity of the Phospholipid efflux pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CINP, ATP6V1D, and DRAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CINP grouped by Phospholipid efflux-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CINP →	-0.717	-1.232	.007	.005	3	6
BONE	ATP6V1D →	-1.104	-1.807	.004	<.001	3	5
LIVER	DRAP1 →	-1.629	-1.520	<.001	<.001	3	5
BREAST	BTN3A3 →	-1.630	-1.171	.001	.001	3	5
LUNG_NSCLC_LUAD	IRF1 →	-0.996	-1.057	<.001	<.001	3	5
CNS	SLC22A4 →	-1.246	-1.193	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CINP by Phospholipid efflux activity — BONE

Explore this box plot interactively →