Phospholipid efflux

Across TCGA cell cohorts, RNA activity of the Phospholipid efflux pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D9B, PPP1R12A, and CNTN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D9B grouped by Phospholipid efflux-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TBC1D9B →	-0.305	-0.433	<.001	.001	3	4
LIVER	PPP1R12A →	-0.405	-0.460	<.001	<.001	3	4
CNS	CNTN5 →	+0.162	+0.184	.001	.008	3	4
SOFT_TISSUE	ST14 →	-0.481	-0.397	<.001	<.001	3	4
PANCREAS	LMAN2L →	-0.202	-0.251	.009	.002	3	3
PANCREAS	PCDHB14 →	+0.214	+0.176	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D9B by Phospholipid efflux activity — LIVER

Explore this box plot interactively →