Positive regulation of osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR1915HG, PRXL2C, and RAB23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIR1915HG grouped by Positive regulation of osteoblast proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MIR1915HG →	+1.720	+1.171	<.001	.001	3	6
LIVER	PRXL2C →	+0.777	+1.091	<.001	.006	3	6
URINARY_TRACT	RAB23 →	+1.089	+1.192	.009	.009	3	6
LIVER	SLAIN2 →	+0.968	+1.043	.004	.009	3	5
LUNG_NSCLC_LUAD	CCN2 →	+2.917	+1.057	.001	<.001	3	5
LARGE_INTESTINE	PEA15 →	+1.352	+1.018	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIR1915HG by Positive regulation of osteoblast proliferation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →