Regulation of osteoblast proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO3, HECTD2, and ARL10, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoblast proliferation activity versus AGO3 in TGCT (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	AGO3 →	+0.676	+0.074	<.001	<.001	3	25
THYM	HECTD2 →	+0.812	+0.061	<.001	<.001	3	25
TGCT	ARL10 →	+0.989	+0.080	<.001	<.001	3	25
TGCT	FAT4 →	+1.437	+0.076	<.001	<.001	3	25
TGCT	MED13L →	+0.718	+0.063	<.001	<.001	3	24
THYM	ARID5B →	+1.436	+0.061	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033688 vs AGO3 — TGCT

Explore this scatter interactively →