Regulation of osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42EP3, RASSF1, and AHNAK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42EP3 grouped by Regulation of osteoblast proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDC42EP3 →	+1.946	+0.565	.001	.002	1	7
BONE	RASSF1 →	+1.385	+1.684	.007	.007	3	5
URINARY_TRACT	AHNAK2 →	+3.042	+1.927	.009	<.001	3	5
LUNG_SCLC	RAB32 →	+2.871	+1.083	.006	.007	3	4
LARGE_INTESTINE	METRN →	+1.121	+0.977	.001	<.001	3	4
LARGE_INTESTINE	MAP7D3 →	+1.400	+1.034	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42EP3 by Regulation of osteoblast proliferation activity — BREAST

Explore this box plot interactively →