Regulation of osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoblast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFR, KCTD14, and FGF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTHFR grouped by Regulation of osteoblast proliferation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MTHFR →	+0.221	+0.946	<.001	.006	3	3
LIVER	KCTD14 →	+0.222	+0.493	.002	.006	3	3
OVARY	FGF1 →	+0.200	+0.260	.003	.002	3	3
PANCREAS	ZNF148 →	-0.209	-0.191	.008	.006	3	3
CNS	MTMR14 →	+0.232	+0.312	.004	.002	2	4
BONE	ATP6V1D →	+0.163	+0.445	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTHFR by Regulation of osteoblast proliferation activity — LUNG_SCLC

Explore this box plot interactively →