Regulation of osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMS1, MRPL53, and IFI16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoblast proliferation activity versus PMS1 in STOMACH (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PMS1 →	+0.408	+0.283	.003	.004	3	4
BONE	MRPL53 →	+0.712	+0.379	.003	<.001	2	5
BREAST	IFI16 →	+2.162	+0.777	.003	.004	3	4
LIVER	HES7 →	+1.302	+0.346	.009	.008	3	4
BLOOD_Myeloma	MFN2 →	+0.430	+1.191	.007	.003	3	3
BLOOD_Myeloma	ROMO1 →	+0.502	+1.231	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033688 vs PMS1 — STOMACH

Explore this scatter interactively →