Osteoblast proliferation

Across TCGA patient cohorts, RNA activity of the Osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED13L, AGO3, and TUT4, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast proliferation activity versus MED13L in THYM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	MED13L →	+0.768	+0.047	<.001	<.001	3	27
TGCT	AGO3 →	+0.650	+0.067	<.001	<.001	3	27
THYM	TUT4 →	+0.792	+0.043	<.001	<.001	3	27
UCS	CEP162 →	+0.656	+0.049	<.001	.001	3	27
SARC	LPP →	+1.440	+0.034	<.001	<.001	3	27
ACC	ZC3H11A →	+0.921	+0.031	<.001	.002	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033687 vs MED13L — THYM

Explore this scatter interactively →