Osteoblast proliferation

Across TCGA patient cohorts, RNA activity of the Osteoblast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OLFML3, TNS2_S120, and SRPK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast proliferation activity versus OLFML3 in BRCA (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OLFML3 →	+0.746	+0.047	<.001	<.001	3	9
BRCA	TNS2_S120 →	+0.488	+0.041	<.001	<.001	3	8
BRCA	SRPK1 →	-0.315	-0.035	<.001	<.001	3	8
BRCA	KANK2 →	+0.551	+0.040	<.001	<.001	3	8
BRCA	SERPING1 →	+0.569	+0.035	<.001	<.001	3	8
OV	TNS2_S102 →	+0.827	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033687 vs OLFML3 — BRCA

Explore this scatter interactively →