Osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FIGNL1, H2AZ2, and POLA2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast proliferation activity versus FIGNL1 in OESOPHAGUS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FIGNL1 →	+1.506	+0.198	<.001	<.001	3	19
BLOOD_Leukemia	H2AZ2 →	+0.880	+0.172	<.001	<.001	3	12
SOFT_TISSUE	POLA2 →	+0.711	+0.101	.003	.008	2	12
OESOPHAGUS	CDK2 →	+1.179	+0.202	<.001	<.001	3	10
SOFT_TISSUE	CENPN →	+0.940	+0.156	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	FAM111B →	+1.284	+0.100	.006	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033687 vs FIGNL1 — OESOPHAGUS

Explore this scatter interactively →