Positive regulation of cell-cell adhesion mediated by integrin

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLRD1, SLAMF1, and CD3G, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-cell adhesion mediated by integrin activity versus KLRD1 in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KLRD1 →	+0.423	+0.577	.003	<.001	3	7
HNSC	SLAMF1 →	+0.693	+0.514	<.001	<.001	3	6
HNSC	CD3G →	+0.918	+0.616	<.001	.001	3	6
LSCC	TNFRSF1B →	+0.755	+0.607	<.001	<.001	3	6
LSCC	SCML4 →	+0.614	+0.528	<.001	<.001	3	6
OV	IL2RB →	+1.106	+1.082	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033634 vs KLRD1 — LSCC

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