Positive regulation of cell-cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by integrin pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR6A1, IFNA13, and GFRA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR6A1 grouped by Positive regulation of cell-cell adhesion mediated by integrin-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NR6A1 →	-0.292	-1.042	<.001	<.001	3	3
SKIN	IFNA13 →	-0.352	-1.616	.003	<.001	3	3
LUNG_NSCLC_LUSC	GFRA4 →	-0.370	-2.019	<.001	<.001	3	3
SKIN	GRSF1 →	-0.164	-1.634	<.001	<.001	3	3
CNS	TTC37 →	-0.253	-1.510	.004	.001	3	3
LUNG_NSCLC_LUSC	THAP9 →	+0.233	+1.959	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR6A1 by Positive regulation of cell-cell adhesion mediated by integrin activity — CNS

Explore this box plot interactively →