Positive regulation of cell-cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL, NUDT21, and OTX1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-cell adhesion mediated by integrin activity versus PODXL in LUNG_NSCLC_LUAD (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PODXL →	+1.702	+1.477	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	NUDT21 →	+1.275	+1.676	.004	.006	3	4
CNS	OTX1 →	+0.646	+1.209	.007	<.001	2	5
CNS	NIT1 →	+0.705	+1.393	<.001	<.001	3	4
BREAST	SPTSSA →	-1.050	-1.371	<.001	<.001	3	4
OESOPHAGUS	H3C6 →	-0.540	-1.261	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033634 vs PODXL — LUNG_NSCLC_LUAD

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