Regulation of cell-cell adhesion mediated by integrin

Across TCGA patient cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRBV20-1, ITGA3, and IRF5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-cell adhesion mediated by integrin activity versus TRBV20-1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRBV20-1 →	+0.746	+0.193	.007	.002	3	5
GBM	ITGA3 →	+0.973	+0.349	.001	<.001	3	5
COAD	IRF5 →	+0.655	+0.288	<.001	.006	3	5
BRCA	CYTH4 →	+0.509	+0.211	<.001	<.001	3	4
BRCA	CSF2RB →	+0.841	+0.175	.005	.006	3	4
BRCA	ST8SIA1 →	+0.641	+0.236	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033632 vs TRBV20-1 — BRCA

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