Regulation of cell-cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX35, SSBP4, and LETM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX35 grouped by Regulation of cell-cell adhesion mediated by integrin-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DHX35 →	-0.437	-0.846	.001	.001	3	5
KIDNEY	SSBP4 →	-0.997	-1.317	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	LETM2 →	+1.734	+1.349	.001	<.001	3	4
BONE	KCNQ4 →	-1.572	-1.363	<.001	.002	3	4
LUNG_NSCLC_LUAD	LHX6 →	-0.848	-0.961	.002	<.001	3	4
SKIN	RPRD1B →	-0.366	-0.733	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX35 by Regulation of cell-cell adhesion mediated by integrin activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →