Regulation of cell-cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL, RPL27A, and DCK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-cell adhesion mediated by integrin activity versus PODXL in LUNG_SCLC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PODXL →	+1.536	+0.981	.004	.008	3	8
BREAST	RPL27A →	+0.745	+1.057	.002	.002	3	5
OESOPHAGUS	DCK →	+0.971	+1.825	<.001	<.001	3	5
LUNG_SCLC	LMAN2 →	-0.815	-1.141	.001	.001	3	5
LIVER	PPP1R1C →	+3.367	+1.875	<.001	<.001	3	4
BLOOD_Leukemia	ZDHHC13 →	+0.778	+0.730	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033632 vs PODXL — LUNG_SCLC

Explore this scatter interactively →