Cell-cell adhesion mediated by integrin

Across TCGA patient cohorts, RNA activity of the Cell-cell adhesion mediated by integrin pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, WAS, and WIPF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell adhesion mediated by integrin activity versus SAMHD1 in HNSC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMHD1 →	+0.623	+0.065	<.001	<.001	3	10
HNSC	WAS →	+0.553	+0.074	<.001	<.001	3	10
HNSC	WIPF1 →	+0.439	+0.083	<.001	<.001	3	10
OV	ADA →	+0.455	+0.087	<.001	<.001	3	10
HNSC	CD4 →	+0.790	+0.110	<.001	<.001	3	10
LSCC	DOCK2 →	+0.680	+0.136	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033631 vs SAMHD1 — HNSC

Explore this scatter interactively →