Cell-cell adhesion mediated by integrin

Across TCGA patient cohorts, RNA activity of the Cell-cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAMF6, CLEC7A, and TRAV17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell adhesion mediated by integrin activity versus SLAMF6 in CCRCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLAMF6 →	+0.694	+0.267	.001	.001	3	6
CCRCC	CLEC7A →	+0.342	+0.206	.007	<.001	3	5
CCRCC	TRAV17 →	+0.600	+0.204	.002	.007	3	5
OV	LCP2 →	+0.745	+0.260	<.001	<.001	3	5
LSCC	IGLV1-44 →	+1.440	+0.257	<.001	<.001	3	5
LSCC	IGHV3-48 →	+0.977	+0.232	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033631 vs SLAMF6 — CCRCC

Explore this scatter interactively →